纳米探针
声动力疗法
荧光
光动力疗法
光化学
生物物理学
纳米材料
铜
荧光寿命成像显微镜
化学
光敏剂
体内
核化学
纳米颗粒
纳米技术
材料科学
有机化学
光学
生物
生物技术
物理
作者
Rongjun Liu,Liangliang Zhang,Jingjin Zhao,Cheng Hou,Yong Huang,Zirong Huang,Shulin Zhao
标识
DOI:10.1002/adtp.201900011
摘要
Abstract Photodynamic therapy (PDT) is a new treatment modality against local lesions, particularly in malignant tumors. However, higher biothiol concentrations in tumor cells will decrease the efficacy of PDT. To tackle the above challenges, a distinctive spinach‐based carbon nanomaterial called “chlorophyll‐rich biomass quantum dots” (CBQDs) with near‐infrared emission is prepared, and the CBQDs are further bound with copper ions forming CBQD‐Cu nanocomposites, which are used as a new fluorescence nanoprobe and highly efficient photosensitizer for simultaneous in vivo near‐infrared fluorescence imaging of biothiol and dual‐enhanced PDT of tumors. The mechanism of action is studied and it is shown that the binding of chlorophyll and copper ions on the surface of CBQDs reduces the energy level difference of the chlorophyll molecules, which results in an increase of reactive oxygen species (ROS) achieving enhanced PDT. On the other hand, the copper ions on the CBQD‐Cu surface can also bind with biothiol which decreases the concentration of free biothiol in tumor cells, and further enhances PDT. At the same time, the combination of copper ions and biothiol opens the fluorescence of CBQDs, which realizes near‐infrared fluorescence imaging of biothiol. Hence, the CBQD‐Cu is used as a highly effective nanomedicine for the recognition and treatment of tumors.
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