新辅助治疗
乳腺癌
医学
病态的
协议(科学)
金标准(测试)
完全响应
医学物理学
采样(信号处理)
化疗
肿瘤科
放射科
病理
癌症
外科
内科学
计算机科学
替代医学
滤波器(信号处理)
计算机视觉
作者
Miralem Mrkonjic,Hal K. Berman,Susan J. Done,Bruce Youngson,Anna Marie Mulligan
标识
DOI:10.1136/jclinpath-2018-205598
摘要
Neoadjuvant systemic therapy is becoming more commonly used in patients with earlier stages of breast cancer. To assess tumour response to neoadjuvant chemotherapy, pathological evaluation is the gold standard. Depending on the treatment response, the pathological examination of these specimens can be quite challenging. However, a uniform approach to evaluate post-neoadjuvant-treated breast specimens has been lacking. Furthermore, there is no single universally accepted or endorsed classification system for assessing treatment response in this setting. Recent initiatives have attempted to create a standardised protocol for evaluation of post-neoadjuvant breast specimens. This review outlines the necessary information that should be collected prior to macroscopic examination of these specimens, the recommended and most pragmatic approach to tissue sampling for microscopic examination, describes the macroscopic and microscopic features of post-therapy breast specimens, summarises two commonly used systems for classifying treatment response and outlines the critical variables that should be included in the final pathology report.
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