生物
甘露糖受体
滋养层
细菌
微生物学
免疫系统
巨噬细胞
巨细胞
受体
吞噬作用
细胞生物学
胎盘
生物化学
体外
免疫学
胎儿
怀孕
遗传学
作者
Masanori Hashino,Masaru Tachibana,Takashi Shimizu,Masahisa Watarai
出处
期刊:Fems Immunology and Medical Microbiology
[Oxford University Press]
日期:2012-12-01
卷期号:66 (3): 427-435
被引量:9
标识
DOI:10.1111/1574-695x.12009
摘要
During pregnancy, maternal immune function is strictly controlled and immune tolerance is induced. Trophoblast giant (TG) cells exhibit phagocytic activity and show macrophage-like activity against microorganisms in the placenta. However, details of molecular receptors and mechanisms for uptake by TG cells have not been clarified. In this study, we investigated the involvement of the mannose receptor, C type 1 (MRC1), in the uptake of the abortion-inducible bacterium Listeria monocytogenes and abortion-uninducible bacteria Bacillus subtilis and Escherichia coli by TG cells differentiated from a mouse trophoblast stem cell line in vitro. Knockdown of MRC1 inhibited the uptake of all of these bacteria, as did the blocking of MRC1 by MRC1 ligands. The uptake of bacteria by MRC1 delayed the maturation of phagolysosomes. These findings suggest that MRC1 plays an important role in the uptake of various bacteria by TG cells and may provide an opportunity for those bacteria to escape from phagosomes.
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