致癌物
转基因生物
转基因水稻
生物
抗原
转基因
肿瘤抗原
生物技术
医学
免疫系统
转基因作物
免疫学
生物化学
基因
免疫疗法
作者
Bahador Hajimohammadi,Gilda Eslami,Elahe Loni,Mohammad Hassan Ehrampoush,Seyed Mohammad Moshtaghioun,Hossein Fallahzadeh,Seyed Ali Yasini Ardakani,Saeedeh Sadat Hosseini,Vahideh Askari
标识
DOI:10.1080/01635581.2021.2012210
摘要
Genetically Modified (GM) foods are among the most important achievements of biotechnology. Given the safety importance of transgenic rice, this study was conducted to investigate the effect of GM rice consumption on serum concentrations of tumor markers in rats. In this experimental intervention, we used the blood serum samples from the Biobank taken from 60 males and 60 female Sprague-Dawley (SD) rats fed on three different diets, including rat’s standard food, non-GM rice, and GM rice after 90 day. Tumor markers including Carcinogenic embryonic antigen (CEA), Alpha-Fito protein (AFP), Cancer Antigen 19-9 (CA19-9), Cancer Antigen 125 (CA125), and Cancer Antigen15-3 (CA15-3) were assessed by enzyme-linked immune sorbent assay (ELISA) method. Statistical analysis was conducted via SPSS software. The results show that the concentrations of tumor markers were within the normal range in the SD rats treated with diet, and since the concentration of tumor markers was lower than the acceptable index determined, according to the kit standard in both groups, no obvious carcinogenic effect was found. However, these findings are not enough to make a final decision regarding the safety assessment of GM rice consumption.
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