光动力疗法
单线态氧
光敏剂
纳米结构
材料科学
纳米颗粒
化学
纳米技术
光化学
氧气
有机化学
作者
Ping Wang,Luwei Zhang,Zhenxi Zhang,Sijia Wang,Cuiping Yao
出处
期刊:Nanomaterials
[MDPI AG]
日期:2022-04-15
卷期号:12 (8): 1358-1358
被引量:1
摘要
Photodynamic therapy (PDT) is a promising tumor therapy and has been proven to be an effective, safe and minimally invasive technique. Hematoporphyrin monomethyl ether (HMME) mediated PDT has been used in clinical treatment of port wine stain (PWS) due to its single component, high yield of singlet oxygen and short light-sensitive period. However, as an amphiphilic photosensitizer, HMME is easy to aggregate due to the presence of a hydrophobic group, which undesirably reduced its generation of singlet oxygen and bioavailability. In this study, we synthesized the stable conjugate of Au@TiO2 core-shell nanostructure with HMME, and the influence of different factors on PTD efficiency were studied. The results showed that the nanostructure had higher PTD efficiency for KB cells than that of HMME. The irradiation wavelength, gold nanoparticle shape and the shell thickness are all important factors for KB cell PDT.
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