免疫系统
间充质干细胞
上皮-间质转换
串扰
生物
逃避(道德)
转移
细胞生物学
癌症研究
免疫学
作者
Riley Mullins,Ananya Pal,Thomas F. Barrett,Molly E. Heft Neal,Sidharth V. Puram
出处
期刊:Cancer Research
[American Association for Cancer Research]
日期:2022-04-01
标识
DOI:10.1158/0008-5472.can-21-4370
摘要
Epithelial-mesenchymal transition (EMT) is a fundamental process that occurs during embryogenesis and tissue repair. However, EMT can be hijacked by malignant cells, where it may promote immune evasion and metastasis. Classically considered a dichotomous transition, EMT in cancer has recently been considered a plastic process whereby malignant cells display and interconvert among hybrid epithelial/mesenchymal (E/M) states. Epithelial-mesenchymal plasticity (EMP) and associated hybrid E/M states are divergent from classical EMT, with unique immunomodulatory effects. Here, we review recent insights into the EMP-immune cross-talk, highlighting possible mechanisms of immune evasion conferred by hybrid E/M states and roles of immune cells in EMP.
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