卵巢癌
疾病
抗药性
液体活检
医学
肿瘤科
内科学
癌症
生物信息学
重症监护医学
生物
微生物学
作者
Mohammad Monirujjaman Khan,Kunwar Somesh Vikramdeo,Sarabjeet Kour Sudan,Seema Singh,Annelise M. Wilhite,Santanu Dasgupta,Rodney P. Rocconi,Ajay K. Singh
标识
DOI:10.1016/j.semcancer.2021.08.005
摘要
Resistance to platinum-based chemotherapy is a major clinical challenge in ovarian cancer, contributing to the high mortality-to-incidence ratio. Management of the platinum-resistant disease has been difficult due to diverse underlying molecular mechanisms. Over the past several years, research has revealed several novel molecular targets that are being explored as biomarkers for treatment planning and monitoring of response. The therapeutic landscape of ovarian cancer is also rapidly evolving, and alternative therapies are becoming available for the recurrent platinum-resistant disease. This review provides a snapshot of platinum resistance mechanisms and discusses liquid-based biomarkers and their potential utility in effective management of platinum-resistant ovarian cancer.
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