医学
肿瘤科
前哨淋巴结
内科学
生物标志物
中性粒细胞与淋巴细胞比率
单变量分析
回顾性队列研究
人口
淋巴结
多元分析
病理
淋巴细胞
癌症
乳腺癌
化学
环境卫生
生物化学
作者
Takuya Maeda,Azusa Hiura,Jiro Uehara,Rino Toyoshima,Tomoe Nakagawa,Koji Yoshino
标识
DOI:10.1016/j.jaad.2021.10.033
摘要
The neutrophil-to-lymphocyte ratio (NLR) is a known prognostic biomarker for survival and is predictive of sentinel lymph node (SLN) positivity in some cancers. However, its usefulness as a prognostic biomarker for cutaneous squamous cell carcinoma (cSCC) has not been fully investigated.Our objective was to investigate the relationship between the NLR and the disease-specific survival and SLN positivity in patients with cSCC.In this single-center retrospective case series, we analyzed patients with cSCC who underwent blood tests prior to the initiation of treatment at our oncology hospital. The relationship between the patients' clinical characteristics (including the NLR) and the disease-specific survival and SLN positivity was evaluated using univariate and multivariate analyses.An elevated NLR was an independent prognostic factor for poor disease-specific survival and a predictive factor for SLN positivity.Limitations include the small number of participants and selection bias due to the large proportion of high-risk cases in our patient population.NLR is a useful biomarker in cSCC because it is simple to measure and can predict prognosis.
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