凝固酶杆菌
随机对照试验
益生菌
非酒精性脂肪肝
肠道菌群
安慰剂
非酒精性脂肪性肝炎
微生物学
胃肠病学
医学
生物
内科学
食品科学
细菌
脂肪肝
生物化学
发酵
病理
替代医学
疾病
遗传学
作者
Rong Hong Hsieh,Yu-Ju Chien,Wan‐Hong Lan,Yung-Kai Lin,Yung-Hsiang Lin,Chi-Fu Chiang,Ming‐Ta Yang
标识
DOI:10.1016/j.cdnut.2024.102083
摘要
BackgroundNonalcoholic fatty liver disease (NAFLD) has become one of the major problems of chronic liver disease worldwide. It not only causes damage to the liver but also engenders chronic hepatitis and cirrhosis. Recent studies have shown that regulating Bacillus coagulans can improve NAFLD.ObjectivesThis trial explores whether B. coagulans TCI711 (BCT) could ameliorate NAFLD.Methods57 NAFLD patients were recruited through FibroScan liver fibrosis scanner and divided into placebo (n= 28) and BCT -supplemented group (n= 29). Specifically, one BCT probiotic capsule was supplemented daily for 8 weeks. Further, the blood, stool, and fatty liver content were then examined.ResultsParameters evaluated for liver and kidney indicators showed no side effects after supplementing BCT. A significant reduction of 8.7% in the fatty liver by, effectively suppressing the grade of fatty liver as revealed by controlled attenuation parameter (CAP). BCT also regulated gut microbiota profiles, with significant increases observed in Bifidobacterium, Eubacterium, Ruminococcaceae, and Sellimonas compared to the baseline.ConclusionsBCT may improve NAFLD by regulating gut microbiota, and parameters evaluated for liver and kidney indicate no side effects.
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