[An introduction to multidisciplinary recommendations for Wilson's disease comprehensive diagnosis and management: 2022 practice guidance from the American Association for the Study of Liver Diseases].

The incidence of Wilson's disease (WD) is global, with an estimated prevalence rate of 30 per million or higher. WD clinical manifestations can be liver disease, progressive neurologic deficits (non evident or even absent liver dysfunction), psychiatric disorders, or a combination of these. Children and younger patients are more likely to develop WD as an isolated liver disease than older patients. Symptoms are often vague and can appear at any age. To that end, in 2022, the American Association for the Study of Liver Diseases published the full version of the WD guidelines and recommendations developed by a panel of experts, providing a modern approach for WD diagnosis and management in an effort to assist clinicians in implementing the most recent diagnostic and management strategies.肝豆状核变性（WD）世界范围内均有发病。患病率约为30/100万甚至更高。WD在临床上可表现为肝脏疾病、进行性神经功能障碍（肝功能障碍不明显或偶尔缺乏）、精神疾病，或以上表现同时出现。WD在儿童和较年轻的成人患者中比在老年人中更容易表现为孤立性肝病。任何年龄段的症状通常都是非特异性的。为此，美国肝病学会于2022年发布了WD指南的完整版本，提供了WD诊断和管理的现代方法。由专家小组制定指南、形成推荐建议，以帮助临床医生实施最新的诊断和管理策略。.