The Blind Spot of Prostate-Specific Membrane Antigen Positron Emission Tomography Staging? Intraductal Carcinoma of the Prostate Is Overrepresented in Patients With No Uptake Pattern on Prostate-Specific Membrane Antigen Positron Emission Tomography and High-Grade Prostate Cancer

In patients who are being considered for radical prostatectomy due to adverse clinical, PI-RADS, or biopsy features, a PSMA PET demonstrating no intraprostatic uptake pattern should not be considered inherently a marker for small-volume or lesser-grade disease. Some high-grade cancers, particularly those associated with IDC-P, may not be well visualized on PSMA PET.