生物
启动(农业)
细胞生物学
先天免疫系统
免疫学
先天性淋巴细胞
树突状细胞
CD8型
T细胞
获得性免疫系统
免疫系统
神经科学
植物
发芽
作者
David A. Christian,Thomas A. Adams,Lindsey Shallberg,Anthony T. Phan,Tony Smith,Mosana Abraha,Joseph A Perry,Gordon Ruthel,Joseph T. Clark,Gretchen Harms Pritchard,Lillian R. Aronson,Selamawit Gossa,Dorian B. McGavern,Ross M. Kedl,Christopher A. Hunter
出处
期刊:Science immunology
[American Association for the Advancement of Science (AAAS)]
日期:2022-09-30
卷期号:7 (75)
被引量:3
标识
DOI:10.1126/sciimmunol.abq7432
摘要
In the peritoneal cavity, the omentum contains fat-associated lymphoid clusters (FALCs) whose role in response to infection is poorly understood. After intraperitoneal immunization with Toxoplasma gondii, conventional type 1 dendritic cells (cDC1s) were critical to induce innate sources of IFN-γ and cellular changes in the FALCs. Unexpectedly, infected peritoneal macrophages that migrated into the FALCs primed CD8+ T cells. Although T cell priming was cDC1 independent, these DCs were required for maximal CD8+ T cell expansion. An agent-based computational model and experimental data highlighted that cDC1s affected the magnitude of the proliferative burst and promoted CD8+ T cell expression of nutrient uptake receptors and cell survival. Thus, although FALCs lack the organization of secondary lymphoid organs, cDC1s resident in this tissue coordinate innate responses to microbial challenge and provide secondary signals required for T cell expansion and memory formation.
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