医学
内科学
多导睡眠图
阻塞性睡眠呼吸暂停
逻辑回归
睡眠呼吸暂停
急性冠脉综合征
疾病
单变量分析
自身抗体
胃肠病学
心脏病学
呼吸暂停
多元分析
免疫学
心肌梗塞
抗体
作者
Takuma Matsumura,Jiro Terada,Taku Kinoshita,Yoriko Sakurai,Misuzu Yahaba,Kenji Tsushima,Seiichiro Sakao,Koichiro Tatsumi,Reiko Kunii
出处
期刊:European Respiratory Journal
日期:2017-09-01
标识
DOI:10.1183/1393003.congress-2017.oa1758
摘要
Moderate-to-severe obstructive sleep apnea (OSA) is known to increase the risk of cardiovascular disease (CVD), but there is no accepted marker of the development of CVD in OSA patients. We evaluated the association of autoantibodies against neuroblastoma suppressor of tumorigenicity 1 (NBL1-Abs) and occurrence of cardiovascular events in OSA patients. Eighty-two adults diagnosed with OSA by polysomnography, 96 patients with a diagnosis of acute coronary syndrome (ACS) and 64 healthy volunteers were evaluated. Serum were collected on polysomnography evaluation from OSA patients, while collected at the onset of ACS from ACS patients. Serum NBL1-Ab level was measured by amplified luminescence proximity homogeneous assay and its association with clinical variables related to atherosclerosis was evaluated. Significant differences in NBL1-Ab level were observed in patients with OSA and ACS compared with healthy volunteers, and NBL1-Ab levels were significantly increased in OSA patients especially with severe OSA and CVD. Univariate and multivariate logistic regression analyses identified elevated NBL1-Ab level as a significant predictor of CVD in OSA patients. Elevated NBL1-Abs may predict increased risk of cardiovascular events in patients with OSA. Patients with higher NBL1-Ab levels may require more careful and intensive treatment.
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