福克斯O1
脂肪肝
转录因子
信号转导
脂联素
甘油三酯
内分泌学
化学
脂质代谢
酒精性脂肪肝
内科学
细胞生物学
生物
生物化学
基因
医学
胆固醇
疾病
肥胖
胰岛素抵抗
出处
期刊:PubMed
日期:2016-11-20
卷期号:24 (11): 877-880
标识
DOI:10.3760/cma.j.issn.1007-3418.2016.11.017
摘要
Long-term alcohol stimulation may inhibit the expression of silent information regulator 1 in hepatocytes, which increases the acetylation level of forkhead box transcription factor O1, reduces nuclear localization, and reduces the binding capacity of DNA sequence. This further downregulates the expression of downstream adiponectin receptor 2 and microsomal triglyceride transfer protein, causes lipid metabolism disorders and triglyceride deposition in hepatocytes by affecting adiponectin signal transduction and synthesis of very-low-density lipoprotein, and finally promotes the development of alcoholic fatty liver disease.
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