抗惊厥药
癫痫
药理学
钠通道
阿米洛利
谷氨酸受体
化学
体内
奥卡西平
神经科学
钠
医学
心理学
生物化学
卡马西平
生物
受体
有机化学
生物技术
作者
Atif Ali,Feroz Ahmad,Yashomati Dua,K. K. Pillai,Divya Vohora
出处
期刊:Cns & Neurological Disorders-drug Targets
[Bentham Science]
日期:2008-10-01
卷期号:7 (4): 343-347
被引量:11
标识
DOI:10.2174/187152708786441830
摘要
Advances in the understanding of mechanisms underlying the pathophysiology of epilepsy have led to the identification of sodium hydrogen exchanger (NHE) as one of the possible targets for future antiepileptic drugs (AEDs). There are indicators from several experimental studies that NHE inhibitors could be of significant value as potential anticonvulsants. Various in-vitro reports (brain slices) have suggested anticonvulsant potential of these agents. Recently we provided the in-vivo data on anticonvulsant efficacy of amiloride (an NHE inhibitor) in different animal models of seizure and epilepsy. In addition to blocking NHE, these agents are known to affect other traditional targets like voltage-gated Na(+) channels, Ca(2+) channels, glutamate concentration, etc. Thus NHE inhibitors may represent a novel class of AEDs and surely deserve more scientific attention. In this review, we focus on the role of NHE in epilepsy and provide the experimental evidence available so far on the effect of NHE inhibitors in various animal models.
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