肿瘤微环境
光动力疗法
癌症
癌症治疗
癌症研究
细胞外基质
免疫系统
化学
医学
纳米技术
肿瘤细胞
免疫学
生物
材料科学
内科学
细胞生物学
有机化学
作者
Chunyong Liang,Xinglin Zhang,Moon-Sik Yang,Wenjun Wang,Peng Chen,Xiaochen Dong
出处
期刊:ACS materials letters
[American Chemical Society]
日期:2020-08-24
卷期号:2 (10): 1268-1286
被引量:39
标识
DOI:10.1021/acsmaterialslett.0c00259
摘要
Photodynamic therapy (PDT) is a clinically implemented modality to tackle intractable diseases, including cancer. Nevertheless, its efficacy is largely compromised by some resistance factors from the complex tumor microenvironment (TME) with various biological barriers. Inspiringly, recent development in nanotechnology has revitalized photodynamic cancer therapy based on rationally designed nanoplatforms that can boost PDT through remodeling TME. Here, we first provide an overview of the microenvironment in solid tumors and the PDT-resistance factors therein. On this basis, we discuss strategies to design multifunctional nanoassemblies and underlying working mechanisms to enhance photodynamic cancer therapy by modulating tumor vasculatures, extracellular matrix, hypoxia, antioxidant defense, and immune suppression. Finally, we highlight the potential and challenges in this burgeoning research field.
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