神经保护
医学
免疫系统
炎症
效应器
小胶质细胞
神经科学
免疫学
获得性免疫系统
调节性T细胞
神经炎症
多发性硬化
免疫
生物
T细胞
白细胞介素2受体
作者
Jatin Machhi,Bhavesh D. Kevadiya,Ijaz Khan Muhammad,Jonathan Herskovitz,Katherine E. Olson,R. Lee Mosley,Howard E. Gendelman
标识
DOI:10.1186/s13024-020-00375-7
摘要
Abstract Emerging evidence demonstrates that adaptive immunity influences the pathobiology of neurodegenerative disorders. Misfolded aggregated self-proteins can break immune tolerance leading to the induction of autoreactive effector T cells (Teffs) with associated decreases in anti-inflammatory neuroprotective regulatory T cells (Tregs). An imbalance between Teffs and Tregs leads to microglial activation, inflammation and neuronal injury. The cascade of such a disordered immunity includes the drainage of the aggregated protein antigens into cervical lymph nodes serving to amplify effector immune responses. Both preclinical and clinical studies demonstrate transformation of this altered immunity for therapeutic gain. We posit that the signs and symptoms of common neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases, amyotrophic lateral sclerosis, and stroke can be attenuated by boosting Treg activities. Graphical Abstract
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