癌症干细胞
癌细胞
CD44细胞
癌症研究
癌变
癌症
核糖体
化学
干细胞
细胞
细胞生物学
材料科学
生物
生物化学
核糖核酸
遗传学
基因
作者
Jian Wang,Baochan Yang,Chunxiao Lv,Tiancheng Chen,Lixin Sun,Lei Sun,Junfeng Hao,Fang Ding,Tianyu Wang,Jianzhuang Jiang,Yan Qin
出处
期刊:Biomaterials
[Elsevier]
日期:2022-10-01
卷期号:289: 121812-121812
被引量:9
标识
DOI:10.1016/j.biomaterials.2022.121812
摘要
Cancer stem cells (CSCs) are the subpopulation of tumor cells with the properties of tumorigenesis, multilineage differentiation potential and self-renewal, which is the driving force of tumor recurrence and metastasis. However, targeting CSCs is still the main challenge in cancer therapy due to their rapid growth and fast mutation rate. Herein, we developed a simple strategy of photodynamic therapy (PDT) targeting CSCs, dependent on much more abundant ribosomes in CSCs. The interactions between positively charged nanoparticles with negatively charged nucleic acids architectures in cancer cells could lead ribosomes targeting as well as CSCs targeting. The co-assembly of simple amino porphyrin (m-TAPP) with short peptide (Fmoc-L3-OMe) formed nanoparticles (NPs) with good biocompatibility and photoactivity, became positively charged due to low pH value of tumour microenvironment, and efficiently accessed cancer cell ribosome, approached cancer cell nuclei, therefore enriched in the fast-amplifying CSCs. The inhibitive effect on CSCs by m-TAPP assemblies was verified by the significant reduction of CSCs markers CD44, CD133 and ribosome amount in cancer cells and tissues. Upon light irradiation, the NPs induced ROS generation to provoke destructive cancer cell ribosome damage and subsequent apoptosis to prevent tumor growth markedly. Based on the assemblies of small organic molecules, our study not only achieves ribosome degradation induced cancer cells apoptosis, but also indicates new possibility of performing CSCs targeting PDT.
科研通智能强力驱动
Strongly Powered by AbleSci AI