偷看
材料科学
透明质酸
自愈水凝胶
表面改性
生物医学工程
骨整合
接触角
化学工程
傅里叶变换红外光谱
化学
复合材料
高分子化学
植入
聚合物
医学
遗传学
外科
工程类
生物
物理化学
作者
Junyan An,Xiaorui Shi,Jun Zhang,Qi Liu,Xue Wang,Xi Nie,Zhihe Yun,Peibiao Zhang,Jian‐guo Liu
标识
DOI:10.1016/j.mtbio.2023.100928
摘要
Polyetheretherketone (PEEK) material has become a potential bone replacement material due to its elastic modulus, which is close to that of human bone, and stable chemical properties. However, its biological inertness has hindered its clinical application. To improve the biological inertia of PEEK material, a hyaluronic acid (HA) hydrogel coating loaded with platelet-rich plasma (PRP) and nerve growth factor (NGF) was constructed on the surface of PEEK material in this study. After the hybrid hydrogel coating was constructed, scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), Fourier transform infrared spectroscopy (FT-IR), degradation tests, and enzyme-linked immunosorbent assays (ELISAs) were used to evaluate its characteristics and biological properties. The osteogenic and angiogenic potentials were also investigated in vitro and in vivo. Our results showed that the HA hydrogel loaded with RPP and NGF on the PEEK surface degraded slowly and could sustainably release various growth factors, including NGF. The results of in vitro tests showed that the hybrid hydrogel on the surface of PEEK effectively promoted osteogenesis and angiogenesis. The in vivo experiment also confirmed that the PEEK surface hydrogel could promote osseointegration of the implant and the integration of new bone and neovascularization. Our results suggest that the cross-linked hyaluronic acid hydrogel loaded with PRP and NGF can significantly improve the biological inertia of PEEK material, endowing PEEK material with good osteogenic and angiogenic ability.
科研通智能强力驱动
Strongly Powered by AbleSci AI