Hot Isostatic Pressing (HIP) is an increasingly used heat treatment process for densifying and enhancing the material properties of components in the aerospace, energy, medical, and additive manufacturing industries. Optimizing HIP cycles and designing efficient HIP furnaces are critical to determine hot-spots, and the computer simulation of the furnace’s processes is indispensable.\n In this study, which addresses the common convergence and the time-consuming issues of traditional simulations, a novel, fully coupled, and highly efficient Computational Fluid Dynamics (CFD) simulation method was employed. This method was utilized to model a complete 25-hour HIP cycle for a three-dimensional, full-scale furnace, including heating, holding, and cooling phases, based on the given furnace power. The advanced approach enables detailed, fully coupled and full-scale 3D computations of all critical processes, such as gas flow, pressure build-up, thermal radiative heat transfer, convective heat transfer, and conjugate heat conduction in solids. The simulation delivers results in a good agreement with the measurement. By avoiding the common pitfalls of error-prone simplifications, this method lays the groundwork for optimizing HIP furnace design and operations.