细菌
抗生素
微生物学
致病菌
抗菌剂
丙烯酸
抗菌活性
化学
脂磷壁酸
多重耐药
水溶液
抗生素耐药性
革兰氏阴性菌
金黄色葡萄球菌
大肠杆菌
生物
生物化学
有机化学
共聚物
基因
聚合物
遗传学
作者
Yoonhee So,DaBin Yim,Sin Lee,Hyunji Lee,Hongwon Kim,Yejoo Yu,Chil-Sung Choi,Jong‐Ho Kim
标识
DOI:10.1016/j.cej.2023.143727
摘要
The abuse and misuse of broad-spectrum antibiotics cause drug resistance in bacteria, which compromises their benefits and thereby increases the demand for new bactericidal mechanisms to reduce the emergence of multidrug-resistant pathogenic bacteria. Herein, ultrathin WSe2 and MoSe2 nanosheets are exfoliated and functionalized with poly(acrylic acid) (PAA) (PAA-WSe2 and PAA-MoSe2) in an aqueous solution as narrow-spectrum or species-specific antibiotics for the treatment of bacterial infections. PAA-WSe2 nanosheets exhibit narrow-spectrum bactericidal activity with low minimum inhibitory concentrations only for gram-positive bacteria, including multidrug-resistant S. aureus, and PAA-MoSe2 displays species-specific antimicrobial activity against S. aureus without external stimuli. Mechanistic studies have revealed that the redox reactions of PAA-WSe2 nanosheets mediated by lipoteichoic acid of gram-positive bacteria to produce a more active element Se4+ are responsible for their narrow-spectrum bactericidal activity against gram-positive bacteria. Finally, the PAA-WSe2 nanosheets effectively eradicate the bacteria in S. aureus-infected mice, leading to excellent therapeutic efficacy in infected wounds. This strategy, based on narrow-spectrum transition metal dichalcogenide antibiotics, can provide an alternative route for the effective treatment of various bacterial infections.
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