Sperm DNA fragmentation and its interaction with female factors

High levels of sperm deoxyribonucleic acid (DNA) fragmentation have been associated with adverse reproductive outcomes, including low natural and assisted pregnancy rates, abnormal embryonic development, and recurrent pregnancy loss. These poor outcomes are likely caused by unrepaired DNA damage exceeding a critical repair threshold, adversely affecting normal embryo development. In these cases, DNA repair mechanisms of the oocyte may play a significant role in compensating for sperm DNA damage, preserving normal embryo development, and enhancing reproductive outcomes.