CTGF公司
牙周纤维
机械转化
牙槽
骨细胞
结缔组织
细胞生物学
化学
软骨
生长因子
刺激
骨吸收
成骨细胞
解剖
内分泌学
内科学
生物
医学
病理
牙科
体外
受体
生物化学
作者
Takashi Yamashiro,Tomohiro Fukunaga,Nobuo Kobashi,Hiroshi Kamioka,Tohru Nakanishi,Masaharu Takigawa,Teruko Takano‐Yamamoto
标识
DOI:10.1177/00220345010800021201
摘要
Connective tissue growth factor (CTGF), which is encoded by an immediate early gene and a member of the CCN family, has been shown to be expressed in osteoblasts, fibroblasts, and chondrocytes. Although CTGF is expressed in bone and cartilage tissues, we tested the hypothesis that CTGF is regulated in mechanotransduction. In the alveolar bone during experimental tooth movement, CTGF mRNA was expressed in osteoblasts and in osteocytes localized around the periodontal ligament under control conditions. Interestingly, 12 hrs after the start of experimental tooth movement, the expression of CTGF mRNA in osteocytes and osteoblasts became more intense around the periodontal ligament, and the intense expression of CTGF extended to osteocytes situated deep in alveolar bone matrix apart from periodontal ligament in both tension and compression sides. Our present findings indicate that CTGF could play a role in regulation of osteocyte function during the mechanical stimulation of bone.
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