猴痘
蛋白质组
计算生物学
病毒学
基因组
生物
注释
遗传学
牛痘
基因
重组DNA
作者
Liangzhen Zheng,Jintao Meng,Mingzhi Lin,Rui Lv,Hongxi Cheng,Lixin Zou,Jinyuan Sun,Linxian Li,Ruobing Ren,Sheng Wang
出处
期刊:Acta Materia Medica
[Compuscript, Ltd.]
日期:2022-01-01
卷期号:1 (2)
被引量:17
标识
DOI:10.15212/amm-2022-0017
摘要
Recently, the monkeypox virus has begun to spread in many countries worldwide [1]. The genome sequence of the monkeypox virus variant responsible for the current outbreak has been reported, thus providing an important resource for better understanding the new variant and accelerating vaccine and drug development. Here, we report structure predictions of the whole proteomes of three monkeypox variants, with annotation of potential small-molecule-binding regions of the proteins. Experimentally determined structures with high similarity to monkeypox proteins were vetted through a structure-alignment algorithm. Our work should help accelerate the development of vaccines and drugs.
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