暴露的
环境流行病学
环境卫生
医学
资源(消歧)
生物监测
一套
数据科学
环境资源管理
计算机科学
环境科学
生态学
生物
地理
考古
计算机网络
作者
David M. Balshaw,Gwen W. Collman,Kimberly A. Gray,Claudia Thompson
出处
期刊:Current Opinion in Pediatrics
[Ovid Technologies (Wolters Kluwer)]
日期:2017-06-01
卷期号:29 (3): 385-389
被引量:51
标识
DOI:10.1097/mop.0000000000000491
摘要
The Children's Health Exposure Analysis Resource (CHEAR) is a new infrastructure supported by the National Institute of Environmental Health Sciences to expand the ability of children's health researchers to include analysis of environmental exposures in their research and to incorporate the emerging concept of the exposome.There is extensive discussion of the potential of the exposome to advance understanding of the totality of environmental influences on human health. Children's health is a logical choice to demonstrate the exposome concept due to the extensive existing knowledge of individual environmental exposures affecting normal health and development and the short latency between exposures and observable phenotypes. Achieving this demonstration will require access to extensive analytical capabilities to measure a suite of exposures through traditional biomonitoring approaches and to cross-validate these with emerging exposomic approaches.CHEAR is a full-service exposure assessment resource, linking up-front consultation with both laboratory and data analysis. Analyses of biological samples are intended to enhance studies by including targeted analysis of specific exposures and untargeted analysis of small molecules associated with phenotypic endpoints. Services provided by CHEAR are made available without cost but require a brief application and adherence to policies detailed on the CHEAR web page at https://chearprogram.org/.
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