肽聚糖
屎肠球菌
糖肽
微生物学
万古霉素
天冬酰胺
生物化学
肽
氨基酸
化学
生物
细菌
细胞壁
抗生素
金黄色葡萄球菌
遗传学
作者
Boudewijn L. M. de Jonge,Douglas A. Gage,Sandra Handwerger
出处
期刊:Microbial Drug Resistance
[Mary Ann Liebert]
日期:1996-01-01
卷期号:2 (2): 225-229
被引量:18
标识
DOI:10.1089/mdr.1996.2.225
摘要
Muropeptide composition of peptidoglycan isolated from isogenic vancomycin-resistant and -sensitive Enterococcus faecium strains was analyzed by reverse-phase high-performance liquid chromatography combined with amino acid and fast atom bombardment mass spectrometric analyses. Peptidoglycan of the sensitive and resistant strains was the same and was composed of tri- and tetrapeptides stem peptide subunits with or without aspartate or asparagine substitutions on the ε-amino group of the lysine residue. Thus, the synthesis of lactate-terminating peptidoglycan precursors in vancomycin-resistant E. faecium did not affect the chemical composition of peptidoglycan.
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