HBx公司
肝细胞癌
乙型肝炎病毒
生存分析
比例危险模型
基因
突变
医学
生物
多元分析
病毒学
肿瘤科
内科学
病毒
癌症研究
遗传学
作者
Ying Xie,Shufeng Li,Yue Zhao,Zhanjun Guo,Jinyi Xu
出处
期刊:Tumor Biology
[SAGE]
日期:2014-07-19
卷期号:35 (10): 10325-10331
被引量:23
标识
DOI:10.1007/s13277-014-2331-0
摘要
Hepatitis B virus (HBV) DNA is prone to mutations because of the proofreading deficiencies of HBV polymerase. The postoperative prognostic value of HBV mutations in HBV X protein (HBx) gene was assessed in HBV associated hepatocellular carcinoma (HCC) patients. The HBx gene was amplified and sequenced, the HBV mutations was identified according to NCBI database ( http://www.ncbi.nlm.nih.gov/genome/5536 ). The relationship between the HBV mutations and HCC survival was compared. Survival curves were generated using the Kaplan–Meier method, and comparisons between the curves were made using the log-rank test. Multivariate survival analysis was performed using a Cox proportional hazards model. After adjusting for clinical characteristics, the following eight mutational sites were identified as statistically significant independent predictors of HCC survival: 1383, 1461, 1485, 1544, 1613, 1653, 1719, and 1753. In addition, the following four mutational sites were identified for their association with survival at a border-line significance level: 1527, 1637, 1674, and 1762/1764. A total of 12 mutations in HBx gene region were identified as independent predictors of postoperative survival in HCC patients. The analysis of HBV DNA mutations may help identify patient subgroups with poor prognosis and may help refine therapeutic decisions regarding HCC patients.
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