A New Methodology for the Reductive Cyclization of ω-Azido Carbonyl Compounds Mediated by Tetrathiomolybdate: Application to an Efficient Synthesis of Pyrrolo[2,1-c][1,4]benzodiazepines

The ω-azido carbonyl compounds on treatment with tetrathiomolybdate, 1 led to the formation of 5, 6 and 7 membered cyclic imines in very good yields under mild conditions. This method is applied successfully to a new efficient synthesis of 1,4-benzodiazapinone derivatives and in particular Bzl DC-81.