接触角
材料科学
甲基丙烯酸酯
粘附
化学工程
傅里叶变换红外光谱
高分子化学
X射线光电子能谱
丙烯酸酯
单宁酸
表面改性
油漆附着力测试
涂层
共聚物
聚合物
纳米技术
化学
有机化学
复合材料
工程类
作者
Long Meng,Kai Pan,Ye Zhu,Wei Wei,Xiaojie Li,Xiaoya Liu
出处
期刊:ACS Biomaterials Science & Engineering
[American Chemical Society]
日期:2018-11-02
卷期号:4 (12): 4122-4131
被引量:13
标识
DOI:10.1021/acsbiomaterials.8b01239
摘要
Herein, a hydrophobized zwitterionic-based copolymer poly(sulfobetaine methacrylate-co-2-(dimethylamino)ethyl methacrylate-co-isobornyl acrylate) (P(SBMA-co-DMA-co-ISA), PSDI) containing a chiral structure has been successfully synthesized by free radical polymerization and subsequent sulfonation reactions. Together with tannic acid (TA), PSDI colloidal particles (CPs) were anchored onto the Ti alloy surface by the electrophoretic deposition method. The composition, morphology, and surface properties of the CP-TA composite coatings were characterized by fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), optical contact angle (OCA), and other methods. The results show that the introduction of TA improves the stability of coatings by participating in the noncovalent interactions including ionic pairing and hydrogen bonding. According to the in vitro bacterial adhesion test, the modified titanium surface containing SBMA and chiral ISA functional units can effectively inhibit Gram-negative bacteria (E. coli) and Gram-positive bacteria (S. aureus) adhesion. Furthermore, the excellent cytocompatibility and favorable cell adhesion and growth behavior of zwitterionic-based coatings were realized as a result of the appropriate hydrophobicity provided by the ISA moiety. This work provides a new strategy for preparing zwitterionic-based multifunctional coating. The coating with excellent bacterial and cell selective adhesion properties has great potential in the applications of metal implant materials, such as cardiovascular stents and human hard tissue repair and replacement materials.
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