纳米颗粒
材料科学
激光器
纳米材料
生物医学中的光声成像
纳米医学
生物物理学
纳米技术
光学
生物
物理
作者
Weizhi Qi,Ting‐Ting Li,Chen Zhang,Fei Liu,Jun Wang,Dandan Chen,Xiaofeng Fang,Changfeng Wu,Kai Li,Lei Xi
标识
DOI:10.1002/adhm.202100569
摘要
Abstract The endothelial barrier plays an essential role in health and disease by protecting organs from toxins while allowing nutrients to access the circulation. However, it is the major obstacle that limits the delivery of therapeutic drugs to the diseased tissue. Here, it is reported for the first time that near‐infrared (NIR) laser pulses can transiently promote the delivery of semiconducting polymer nanoparticles passing the vascular barrier via photoacoustic‐effect‐induced accumulation, only by the aid of pulse laser irradiation. This strategy enables selective and substantial accumulation of the NIR‐absorbing nanoparticles inside specific tissues, implying the discovery of an unprecedented approach for light‐controlled nanoparticle delivery. Especially, the nanoparticle delivery in solid tumors by 10‐min laser scanning is approximately six times higher than that of the enhanced permeability and retention (EPR) effect in 24 h under current experimental conditions. Further results confirm that this strategy facilitates substantial accumulation of nanoparticles in the mouse brain with intact skull. This approach thus opens a new door for tissue‐specific delivery of nanomaterials with an unprecedented level of efficiency and precision.
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