二尖瓣夹子
医学
心脏病学
内科学
心房颤动
射血分数
二尖瓣反流
功能性二尖瓣反流
心力衰竭
心室
二尖瓣
二尖瓣修补术
相伴的
作者
Antonio Popolo Rubbio,Luca Testa,Carmelo Grasso,Antonio Sisinni,Maurizio Tusa,Eustachio Agricola,Federico De Marco,Anna Sonia Petronio,Matteo Montorfano,Rodolfo Citro,Marianna Adamo,Antonio Mangieri,Matteo Casenghi,Anna Lisa Milici,Laura Stazzoni,Antonio Colombo,Corrado Tamburino,Francesco Bedogni
标识
DOI:10.1016/j.ijcard.2021.11.027
摘要
A-FMR is considered a specific sub-type of secondary MR in patients with atrial fibrillation (AF) and preserved left ventricle ejection fraction (LVEF). Aim of the study was to investigate the acute and mid-term outcomes of transcatheter edge-to-edge mitral valve repair (TMVr) with the MitraClip in atrial functional mitral regurgitation (A-FMR).The study included patients with A-FMR and concomitant AF who underwent to the MitraClip at 7 Italian Centers. Aim of the study was to assess the safety, efficacy and mid-term cardiovascular outcomes.After reviewing 1153 patients with FMR treated with TMVr from 2009 to 2021, 87 patients (median age 81 years, 61% female) with A-FMR were identified. Technical success was achieved in 97%, 30-day device success in 83% and 30-day procedural success in 80%. All-cause death at 30-day was 5%. Estimated two-year freedom from all-cause death and cardiac death was 60% and 77%, respectively, whereas freedom from all-cause death/heart failure hospitalization was 55%. Residual MR ≤ 2+ was encountered in 89% (n = 47/53) and improvement in NYHA class I/II in 79% (n = 48/61). Post-procedural MR ≥ 2+ (HR 5.400, CI 1.371-21.268) and inter-commissural annular diameter ≥ 35 mm (HR 4.159, CI 1.057-16.363) were independent predictors of all-cause death/heart failure hospitalization during the follow-up. Positive reverse remodeling of left atrium and mitral annular dimensions occurred after TMVr during the follow-up.MitraClip resulted to be a safe and effective option to treat A-FMR in elderly patients.
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