经胎盘
医学
四分位间距
胎龄
儿科
逻辑回归
怀孕
效价
病毒
免疫学
胎儿
内科学
生物
胎盘
遗传学
作者
Nusrat Homaira,Michael J. Binks,G. J. Walker,Natasha Larter,Katrina Clark,Megan Campbell,Lisa McHugh,Nancy Briggs,Joyce U. Nyiro,Sacha Stelzer‐Braid,Nan Hu,Kristine Macartney,Tom Snelling,Saad B. Omer,William Rawlinson,Ross M. Andrews,Adam Jaffé
摘要
Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory infection hospitalisations in Aboriginal infants specifically those aged <6 months. Maternally derived RSV antibody (Ab) can protect against severe RSV disease in infancy. However, the efficiency of transplacental transfer of maternal anti-RSV Ab remains unknown in Aboriginal infants. We characterised RSV Ab in Australian First Nations mother-infant pairs (n = 78). We investigated impact of covariates including low birthweight, gestational age (GA), sex of the baby, maternal age and multiparity of the mother on cord to maternal anti-RSV Ab titre ratio (CMTR) using multivariable logistic regression model. All (n = 78) but one infant was born full term (median GA: 39 weeks, interquartile range: 38-40 weeks) and 56% were males. The mean log2 RSV Ab titre was 10.7 (SD± 1.3) in maternal serum and 11.0 (SD ± 1.3) in cord serum at birth; a ratio of 1.02 (SD ± 0.06). One-third of the pairs had a CMTR of <1 indicating impaired transfer. Almost 9% (7/78) of the term infants had cord RSV Ab levels below
科研通智能强力驱动
Strongly Powered by AbleSci AI