自噬
免疫系统
获得性免疫系统
先天免疫系统
生物
细胞生物学
免疫
信号转导
免疫学
经典补体途径
细胞凋亡
补体系统
生物化学
作者
Bing Cui,Heng Lin,J. Jessica Yu,Zhuowei Hu
标识
DOI:10.1007/978-981-15-0602-4_27
摘要
Innate immunity and adaptive immunity play critical roles in maintaining normal physiological functions and the development of diseases. In innate immune responses, heterogeneous autophagy can directly remove intracellular pathogens while activating PRRs, including TLRs and NLRs, to trigger their signal transduction pathways and promote NKT cell activation, cytokine secretion, and phagocytosis. In adaptive immune responses, the autophagy reaction has an important effect on the homeostasis, function, and differentiation of T lymphocytes, the survival, and development of B lymphocytes and the survival of plasma cells. This review highlights the key role that autophagy plays in the innate immune system and the acquired immune system. Further clarifying the mechanism by which autophagy regulates the immune system is essential for elucidating the precise mechanisms of various diseases and for developing new treatment methods.
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