[Clinical significance and correlation of ductular reaction in hepatobiliary diseases].

Ductular reaction is a kind of repair response to biliary and hepatocellular injury, and the pathological changes include lobular bile duct hyperplasia, matrix change and inflammatory cell infiltrations. In human liver, a ductular reaction originates from the activation and proliferation of hepatic progenitor cells. The activated hepatic progenitor cells, the intermediate hepatocytes and the reactive small bile duct cells together form the cell complex of ductular reaction, which has the dual characteristics of hepatobiliary system and co-expresses the hepatocyte and cholangiocyte antigen. Ductular reaction appears in all kinds of acute and chronic hepatobiliary injury, and plays an important role in liver regeneration and repair, fibrogenesis, cirrhosis formation, and hepatobiliary cancer occurrence and development. Understanding the pathological features and pathophysiological mechanisms of ductular reaction in various clinical hepatobiliary diseases and their role in liver regeneration can provide important suggestion for further exploring new-targeted treatment approach.胆管反应是一种对肝胆细胞损伤的修复反应，特征病理变化包括小叶间胆管增生、基质变化和炎症细胞浸润。人体肝脏的胆管反应源于肝祖细胞的活化增殖。活化的肝祖细胞、中间型肝胆细胞和反应性小胆管细胞共同组成胆管反应的细胞复合体，该细胞复合体具有肝胆系双重特征，共表达肝细胞和胆管细胞抗原。胆管反应出现在各种急慢性肝胆损伤中，在肝脏再生修复、肝脏纤维化发生和发展、肝硬化形成，以及肝胆管癌的发生和发展中均有重要参与作用。了解胆管反应在各种临床肝胆疾病中的病理学特征、发生和发展机制，及其在肝再生中的作用，可以为进一步发掘肝脏疾病靶向治疗的新途径提供重要参考。.