胰腺癌
吉西他滨
肽
癌症研究
细胞生长
毒性
癌细胞
2尼泊尔卢比
内科学
癌症
化学
生物
内分泌学
利钠肽
药理学
生物化学
医学
心力衰竭
作者
Michael R. Kozlowski,Roni E Kozlowski
出处
期刊:PubMed
日期:2020-01-01
卷期号:10 (5): 1356-1365
被引量:4
摘要
KTH-222 is a novel, 8-amino acid length peptide. It is derived from a motif identified in a group of peptides that are related to atrial natriuretic peptide and that are able to inhibit cancer cell growth. We report here that KTH-222 inhibits the attachment, proliferation, and development of an invasive morphology in cultured human pancreatic tumor cells (MIA PaCa-2 and HPAC). At a biochemical level, it inhibits tubulin polymerization which may underlie these cellular effects. We further report that KTH-222 reduces the rate of tumor growth and prolongs survival in mice implanted with MIA PaCa-2 cells. In this model system, KTH-222 is more effective than gemcitabine, a drug commonly used in the treatment of pancreatic cancer. Furthermore, KTH-222 does not decrease the rate of weight gain in the treated mice, suggesting the absence of gross toxicity. These activities of KTH-222 suggest that it may be useful in the treatment of pancreatic cancer.
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