生物
配子发生
表观遗传学
染色质
DNA甲基化
胚胎
生殖技术
组蛋白
转录组
后生
中国
遗传学
胚胎发生
进化生物学
细胞生物学
计算生物学
DNA
基因
基因表达
政治学
法学
作者
Qiang Liu,Xi Chen,Jie Qiao
标识
DOI:10.1093/biolre/ioac134
摘要
Abstract Reproductive medicine in China has developed rapidly since 1988 due to support from the government and scientific exploration. However, the success rate of assisted reproduction technology is around 30–40% and many unknown “black boxes” in gametogenesis and embryo development are still present. With the development of single-cell and low-input sequencing technologies, the network of transcriptome and epigenetic regulation (DNA methylation, chromatin accessibility, and histone modifications) during the development of human primordial germ cells, gametes, and embryos has been investigated in depth. Furthermore, preimplantation genetic testing has also rapidly developed. In this review, we summarize and analyze China’s outstanding progress in these fields.
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