Inside Cover: Synthesis of Chiral Covalent Organic Frameworks via Asymmetric Organocatalysis for Heterogeneous Asymmetric Catalysis (Angew. Chem. Int. Ed. 25/2022)

A universal organocatalytic asymmetric polymerization approach for the synthesis of chiral covalent organic frameworks (CCOFs) under ambient conditions is developed by Bing-Jian Yao, Yu-Bin Dong et al. in their Research Article (e202115044). With a chiral 2-methylpyrrolidine catalyst, a series of tris(N-salicylideneamine)-derived β-ketoenamine CCOFs were constructed from prochiral monomers via Schiff-base condensation. The metalated CCOFs promote asymmetric A3-coupling reactions at a gram-scale level in a fixed-bed model reactor.