钯
区域选择性
化学
杂原子
反应性(心理学)
环加成
脱羧
催化作用
有机化学
组合化学
戒指(化学)
医学
病理
替代医学
作者
Yong You,Qun Li,Yanping Zhang,Jian‐Qiang Zhao,Zhenhua Wang,Wei‐Cheng Yuan
出处
期刊:Chemcatchem
[Wiley]
日期:2022-02-21
卷期号:14 (9)
被引量:44
标识
DOI:10.1002/cctc.202101887
摘要
Abstract Palladium‐catalyzed decarboxylative cycloadditions have emerged as highly effective methods for constructing structurally diverse carbo‐ and heterocycles because of the formation of at least two carbon‐carbon or carbon‐heteroatom bonds in a single step. It is of great interest to chemists that this type of cycloaddition reactions possesses some special advantages such as high reactivity, exclusive regioselectivity, and good functional group compatibility. Based on these qualities, palladium‐catalyzed decarboxylative cycloadditions present strong ability in synthetic chemistry and have been flourished especially in the last five years. In this review, the achievements in palladium‐catalyzed decarboxylative cycloadditions involving cyclic carbonates, carbamates, and lactones for accessing oxacyclo‐, azacyclo‐ and carbocyclic compounds are addressed. Mechanistic insights and some synthetic applications toward the synthesis of natural products are discussed. The challenges and opportunities of this field are also outlined.
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