Regioselective Anomeric O ‐Benzyl Deprotection in Carbohydrates

Abstract A highly regioselective hydrogenolysis of the anomeric benzyl group is reported. The reaction involves selective acetolysis of benzyl acetals of various mono‐ and di‐saccharides using 10 % Pd/C under hydrogen atmosphere in the presence of Na 2 CO 3 . The generality of the methodology is evaluated by applying it to a number of perbenzylated/orthogonally protected benzyl glycosides.