寨卡病毒
小头畸形
医学
怀孕
无意识
心室肥大
传输(电信)
病毒学
抗病毒药物
免疫学
胎儿
儿科
病毒
生物
工程类
电气工程
基因
生物化学
遗传学
作者
Cecília Benazzato,Fabiele Baldino Russo,Patrícia Cristina Baleeiro Beltrão-Braga
标识
DOI:10.1080/17460441.2021.1973999
摘要
Congenital Zika syndrome is caused by Zika virus (ZIKV) infection during pregnancy and can culminate in structural and neurological defects in the fetus, including a spectrum of symptoms such as brain calcifications, hydrocephalus, holoprosencephaly, lissencephaly, ventriculomegaly, and microcephaly. Using animal models to study ZIKV infection during pregnancy represents a critical tool for understanding ZIKV pathophysiology, drug testing, vaccine development, and prevention of vertical transmission.In this review, the authors cover state-of-the-art preclinical pregnancy models of ZIKV infection for drug discovery and vaccine development to prevent vertical transmission.The discovery of drugs against ZIKV infection represents an urgent necessity, and until now, no effective drug that can prevent the effects of vertical transmission has been tested in humans. Even after six years of the ZIKV outbreak in Brazil, no drugs or vaccines have been approved for use in humans. In part, this failure could be related to the lack of translatability from available preclinical models to humans.
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