FTO基因
小分子
脱甲基酶
癌症研究
癌症
基因
肥胖
化学
医学
药理学
生物
内科学
生物化学
表观遗传学
基因型
多态性(计算机科学)
作者
Shuting Gao,Xitong Li,Miao Zhang,Ning Zhang,Ruiyong Wang,Junbiao Chang
出处
期刊:Future Medicinal Chemistry
[Newlands Press Ltd]
日期:2021-09-01
卷期号:13 (17): 1475-1489
被引量:3
标识
DOI:10.4155/fmc-2021-0132
摘要
Studies have shown that the FTO gene is closely related to obesity and weight gain in humans. FTO is an N6-methyladenosine demethylase and is linked to an increased risk of obesity and a variety of diseases, such as acute myeloid leukemia, type 2 diabetes, breast cancer, glioblastoma and cervical squamous cell carcinoma. In light of the significant role of FTO, the development of small-molecule inhibitors targeting the FTO protein provides not only a powerful tool for grasping the active site of FTO but also a theoretical basis for the design and synthesis of drugs targeting the FTO protein. This review focuses on the structural characteristics of FTO inhibitors and discusses the occurrence of obesity and cancer caused by FTO gene overexpression.
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