活性氧
线粒体
氧化磷酸化
氧化应激
疾病
阿尔茨海默病
生物
神经科学
细胞生物学
化学
生物化学
医学
病理
作者
Claus Desler,Meryl S. Lillenes,Tone Tønjum,Lene Juel Rasmussen
标识
DOI:10.2174/0929867324666170616110111
摘要
The current molecular understanding of Alzheimer’s disease (AD) has still not resulted in successful interventions. Mitochondrial dysfunction of the AD brain is currently emerging as a hallmark of this disease. One mitochondrial function often affected in AD is oxidative phosphorylation responsible for ATP production, but also for production of reactive oxygen species (ROS) and for the de novo synthesis of pyrimidines. This paper reviews the role of mitochondrial produced ROS and pyrimidines in the aetiology of AD and their proposed role in oxidative degeneration of macromolecules, synthesis of essential phospholipids and maintenance of mitochondrial viability in the AD brain.
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