先天免疫系统
纳米载体
信使核糖核酸
核酸
免疫系统
体内
细胞生物学
计算生物学
纳米技术
生物
化学
基因
药物输送
免疫学
生物化学
遗传学
材料科学
作者
Yasmin Granot,Dan Peer
标识
DOI:10.1016/j.smim.2017.08.015
摘要
mRNA molecules hold tremendous potential as a tool for gene therapy of a wide range of diseases. However, the main hurdle in implementation of mRNA for therapeutics, the systemic delivery of mRNA molecules to target cells, remains a challenge. A feasible solution for this challenge relies in the rapidly evolving field of nucleic acid-loaded nanocarriers and specifically in the established family of lipid-based nanoparticles (LNPs). Herein, we will discuss the main factors, which determine the fate of modified mRNA (mmRNA)-loaded LNPs in-vivo, and will focus on their interactions with the innate immune system as a main consideration in the design of lipid-based mmRNA delivery platforms.
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