体重不足
骨矿物
脂肪因子
医学
内分泌学
内科学
瘦体质量
骨量减少
骨重建
脂联素
骨质疏松症
骨密度
骨钙素
骨吸收
瘦素
肥胖
超重
化学
体重
胰岛素抵抗
碱性磷酸酶
酶
生物化学
作者
Jadwiga Ambroszkiewicz,Witold Klemarczyk,Grazna Rowicka,Magdalena Chełchowska,Mariusz Ołtarzewski,Joanna Gajewska
出处
期刊:PubMed
日期:2015-07-01
卷期号:39 (229): 18-22
被引量:1
摘要
One of the important factors affecting bone health is body weight. Underweight children are predisposed to disturbances in bone metabolism, which may result in osteopenia and osteoporosis in later life.The aim of the study was to assess the relationship between adipokines, bone metabolism, and anthropometric parameters in underweight prepubertal children.The study included 60 children aged 5-10 years. Among them, there were: 30 underweight children (BMI z-score ≤-1) and 30 normal-weight children (BMI z-score <-1 + 1 >). Body composition (fat mass, lean body mass, bone mass) and bone mineral density examination were performed by densitometry. Serum concentrations of bone metabolism markers and adipokines were determined by immunoenzymatic methods.In underweight children we observed significantly lower fat mass (p<0.0001), lean mass (p<0.001), bone mineral content (p<0.01) and bone mineral density both the total body (p<0.01) as well as lumbar spine L2-L4 (p<0.05) compared with normal-weight children. In the group of underweight children, serum concentration of bone resorption marker (CTX) was significantly higher than in normal-weight children (2.006±0.649 vs. 1.624±0.492 ng/ml, p<0.05), with no differences in the concentrations of osteocalcin and sclerostin between studied groups. The ratio of adipokines (leptin/adiponectin) was approximately 2-fold lower in underweight than in normal-weight subjects. In underweight children we observed positive correlations between concentrations of sclerostin and bone turnover markers (OC, CTX) and between adiponectin and CTX. However, there was no correlation between fat mass and leptin concentration in this group of children.Low body weight in prepubertal period is related with an alteration in the adipokines profile and bone metabolism markers, resulting in a decrease in bone mineral density.
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