甲基乙烯基酮
废止
烯醇
化学
酮
三氟化硼
有机化学
丙酮
路易斯酸
烯醇醚
烷基
迈克尔反应
药物化学
催化作用
作者
Pierre Duhamel,Gilles Dujardin,Laurent Hennequin,Jean‐Marie Poirier
出处
期刊:Journal of the Chemical Society
日期:1992-01-01
卷期号: (3): 387-387
被引量:45
摘要
A new annulation method is presented, involving a boron trifluoride catalysed Michael addition of trialkylsilyl enol ethers to methyl vinyl ketone (MVK) in the presence of a hydroxylic compound. This methodology allows regiospecific 3-oxobutylation of either of the two isomeric enol ethers of mono or di-substituted cyclanones. Octalones 2d, e and hydrindenones 17 with the two alkyl groups in a cis relationship can thus be specifically obtained. This method has been applied to a short and efficient preparation of (±)-dehydrofukinone 10.
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