氢胺化
对映选择合成
化学
烯丙基重排
二胺
邻接
催化作用
铜
功能群
组合化学
有机化学
聚合物
作者
Saki Ichikawa,Xi‐Jie Dai,Stephen L. Buchwald
出处
期刊:Organic Letters
[American Chemical Society]
日期:2019-05-17
卷期号:21 (11): 4370-4373
被引量:38
标识
DOI:10.1021/acs.orglett.9b01592
摘要
A highly regio- and enantioselective synthesis of 1,2-diamine derivatives from γ-substituted allylic pivalamides using copper-catalyzed hydroamination is reported. The N-pivaloyl group is essential, in both facilitating the hydrocupration step and suppressing an unproductive β-elimination from the alkylcopper intermediate. This approach enables an efficient construction of chiral differentially protected vicinal diamines under mild conditions with broad functional group tolerance.
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