芴酮
化学
芴
反应性(心理学)
环加成
肟
硝基
有机化学
高分子化学
催化作用
聚合物
医学
病理
替代医学
作者
Dong-Liang Mo,Donald A. Wink,Laura L. Anderson
出处
期刊:Organic Letters
[American Chemical Society]
日期:2012-10-09
卷期号:14 (20): 5180-5183
被引量:65
摘要
N-Vinyl nitrones derived from fluorenone have been prepared via a copper-mediated coupling between fluorenone oxime and vinyl boronic acids. These compounds undergo subsequent rearrangement and addition reactions that are distinct from the traditional [3 + 2] cycloaddition reactivity of nitrones. Thermal rearrangements of fluorenone N-vinyl nitrones give spiroisoxazolines, while treatment with alkynes provides fluorene-tethered isoxazoles. The scope and limitations of the preparation of fluorenone N-vinyl nitrones and their subsequent rearrangement and addition reactions are discussed.
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