痤疮
皮脂腺
过氧化物酶体增殖物激活受体
脂质代谢
内分泌学
激活剂(遗传学)
内科学
内生
受体
转录因子
过氧化物酶体
脂肪组织
生物
花生四烯酸
医学
生物化学
基因
酶
遗传学
作者
Anikó Dózsa,Johanna Mihály,Balázs Dezső,Eva Csizmadia,T. Keresztessy,Lóránt Markó,Ralph Rühl,Éva Remenyik,László Nagy
摘要
Little is known about the altered lipid metabolism-related transcriptional events occuring in sebaceous glands of patients with acne vulgaris. Peroxisome proliferator-activated receptor (PPAR)γ, a lipid-activated transcription factor, is implicated in differentiation and lipid metabolism of sebocytes. We have observed that PPARγ and its target genes, ADRP (adipose differentiation related protein) and PGAR (PPARγ angioprotein related protein) are expressed at lower levels in sebocytes from patients with acne than in those from healthy controls (HCs) Furthermore, endogenous PPARγ activator lipids such as arachidonic acid-derived keto-metabolites (e.g. 5KETE, 12KETE) are increased in acne-involved and nonacne-involved skin of patients with acne, compared with skin from healthy individuals. Our findings highlight the possible anti-inflammatory role of endogenous ligand-activated PPARγ signaling in human sebocyte biology, and suggest that modulating PPARγ- expression and thereby signaling might be a promising strategy for the clinical management of acne vulgaris.
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