PI3K/AKT/mTOR通路
免疫系统
信号转导
机制(生物学)
细胞生物学
细胞代谢
生物
mTORC2型
细胞
mTORC1型
免疫学
生物化学
哲学
认识论
出处
期刊:PubMed
日期:2024-01-01
卷期号:40 (1): 69-73
摘要
In the tumor microenvironment, metabolic reprogramming can impact metabolic characteristics of T cells, thus inducing immunosuppression to promote tumor immune escape. The mammalian target of rapamycin (mTOR) signaling pathway plays an important role in regulating diverse functions of various immune cells. This review mainly focuses on the molecular mechanism of mTOR signaling in regulating cellular energy metabolism process, and the activation status of mTOR signaling under different nutritional environments. In addition, it also summarizes the role of the mTOR signaling in regulatory T cell (Tregs) metabolism and function in current studies, and evaluates the potential of mTOR as a clinical immunotherapeutic target and its current application challenges.
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