纳米技术
药物输送
生物相容性
纳米材料
生物高聚物
癌症治疗
光热治疗
涂层
靶向给药
化学
材料科学
聚合物
癌症
医学
有机化学
内科学
作者
Takwa Bedhiafi,Sourour Idoudi,Areej Ali Alhams,Queenie Fernandes,Heba Iqbal,Renuka Basineni,Shahab Uddin,Said Dermime,Maysaloun Merhi,Nashiru Billa
标识
DOI:10.1016/j.jconrel.2022.12.037
摘要
Polydopamine (PDA) is a biopolymer with unique physicochemical properties, including free-radical scavenging, high photothermal conversion efficiency, biocompatibility, biodegradability, excellent fluorescent and theranostic capacity due to their abundant surface chemistry. Thus, PDA is used for a myriad of applications including drug delivery, biosensing, imaging and cancer therapy. Recent reports present a new functionality of PDA as a coating nanomaterial, with major implications in mucosal drug delivery applications, particularly muco-adhesion and muco-penetration. However, this application has received minimal traction in the literature. In this review, we present the physicochemical and functional properties of PDA and highlight its key biomedical applications, especially in cancer therapy. A detailed presentation of the role of PDA as a promising coating material for nanoparticulate carriers intended for mucosal delivery forms the core aspect of the review. Finally, a reflection on key considerations and challenges in the utilizing PDA for mucosal drug delivery, along with the possibilities of translation to clinical studies is expounded.
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